Critically elucidating the role of selenium

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However, this effect was not due to GPx1 activity or Pro198Leu polymorphism.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

RESULTS: A total of 110 consecutive patients were evaluated.

The mean age was 57.6 ± 15.9 years, 63.6% were male.

INTRODUCTION: Selenoenzymes can modulate the extent of oxidative stress, which is recognized as a key feature of septic shock.

The pathophysiologic role of erythrocyte selenium concentration in patients with septic shock remains unknown.

In the logistic regression models, erythrocyte selenium concentration was associated with ICU and hospital mortality in patients with septic shock even after adjustment for protein carbonyl concentration and acute physiology and chronic health evaluation II score (APACHE II) or sequential organ failure assessment (SOFA).

critically elucidating the role of selenium-28critically elucidating the role of selenium-51critically elucidating the role of selenium-42

Blood samples were taken within the first 72 hours of the patients’ admission or within 72 hours of the septic shock diagnosis for determination of selenium status, protein carbonyl concentration, GPx1 activity and GPx1 Pro198Leu polymorphism (rs 1050450) genotyping.A total of 110 consecutive patients were evaluated. Regarding selenium status, only erythrocyte selenium concentration was lower in patients who died in the ICU.Overall cellular oxidative burden is regulated by a balance between the rates of reactive oxygen species (ROS) generation and a variety of antioxidant enzymes/pathways.At the time of the patients' enrollment, demographic information was recorded.Blood samples were taken within the first 72 hours of the patients' admission or within 72 hours of the septic shock diagnosis for determination of selenium status, protein carbonyl concentration, GPx1 activity and GPx1 Pro198Leu polymorphism (rs 1050450) genotyping.

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